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Pain School
Pain School
an educational project of IASP an educational project of IASP an educational project of IASP


EPS 2017: CNS vs PNS Contributions to Persistent Pain

CNS vs PNS Contributions to Persistent Pain

Siena, Italy • 4-11 June 2017

Siena, Italy • 4-11 June 2017



Ln Faculty Lectures (L1-L19)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W10)
Sn Scholars’ Oral Presentations (S1-S31)

  • Sunday, 4 June

    11:00-17:00 Arrival of Scholars and Faculty at the Certosa di Pontignano
    15:30-16:30 A short guided tour through the Certosa, its Chapel, Cloisters and Garden
    17:00-18:30 Opening Ceremony

    L1 Welcome
    Anna Maria Aloisi, School Director, Siena Italy

    The European Pain School 2017
    Bill Maixner, Durham, NC, USA

    Greetings from the University of Siena

    With passion against pain
    Gaby Erkens, Grünenthal Scientific Relations Management

    Pain: a new scientific discipline
    Marshall Devor, Jerusalem, Israel

    The Certosa di Pontignano and its history
    Giancarlo Carli, Siena, Italy

    Monasteries, the medieval forerunners of Universities and Hospitals
    Manfred Zimmermann, Heidelberg, Germany

    Scholars’ self-introduction

    18:30 Wine reception followed by dinner, then leisure time


  • Monday, 5 June

    9:00-10:00 L2 Neuroplasticity – a neurophysiological introduction
    Manfred Zimmermann (Heidelberg, Germany)
      Scholars’ oral presentations
    10:00-10:15 S1 Restoration of descending pain inhibition by tapentadol
    Christian Elling (Aachen, Germany)
    10:15-10:30 S2 Temperature and carryover related to pain intensity during quantitative sensory testing in migraine patients
    Shana Burrowes (Baltimore, MD, USA)
    10:30-11:00 Coffee break
    11:00-11:15 S3 Secondary hyperalgesia is mediated by heat-insensitive A-fibre nociceptors
    Cédric Lenoir (Brussels, Belgium)
    11:15-11:30 S4 Pain at its source: signal transduction at the nociceptive peripheral terminals
    Robert Goldstein (Jerusalem, Israel)
    11:30-12:30 L3 PNS plasticity: hyperexcitable neurons as generators of spontaneous and evoked pain
    Marshall Devor (Jerusalem, Israel)
    13:00-15:00 Lunch break
    15:00-16:00 L4 Plasticity in the somatosensory system
    Tamar Makin (London, UK)
      Scholars’ oral presentations
    16:00-16:15 S5 Transcranial focused ultrasonic brain stimulation: a novel non-invasive technique to modulate or study pain in humans
    Julien Lambert (Brussels, Belgium)
    16:15-16:30 S6 Alterations of astrocytic and neuronal function in the anterior cingulate cortex of a migraine mouse model
    Jennifer Romanos (Zurich, Switzerland)
    16:30-17:00 Coffee break
    17:00-17:15 S7 Association of Apolipoprotein E gene polymorphism with pain states in subjects having musculoskeletal disorders
    Harjot Dhillon (Patiala, India)
    17:15-17:30 S8 Body representation in Complex Regional Pain Syndrome and its association with physical symptoms
    Axel Vittersø (Bath, UK)
    17:30-18:30 L5 Novel mechanisms of pain mediated by autoantibodies in conditions like rheumatoid arthritis?
    Camilla Svensson (Stockholm, Sweden)
    20:00-21:30 Dinner in the small Cloister
    21:30 W1 Behavioral tests & tools in pain research, a hands-on presentation of equipment for experimental pain research
    Federico Oggioni (Ugo Basile Srl. Gemonio, Varese, Italy)


  • Tuesday, 6 June

    9:00-10:00 L6 Role of HMGB1 and TLR4 in spinal nociceptive signal transmission in models of arthritis-induced pain
    Camilla Svensson (Stockholm, Sweden)
      Scholars’ oral presentations
    10:00-10:15 S9 Pain responses and behavioral disturbances in CD1 mice during acute and chronic phases after spinal cord injury
    Silvia Castany Quintanag (Girona, Spain)
    10:15-10:30 S10 Bifunctional hybrid compounds: towards improved neuropathic pain treatments
    Joanna Starnowska (Krakow, Poland)
    10:30-11:00 Coffee break
    11:00-11:15 S11 Collagens modulate sensitization signaling and CGRP expression of nociceptive neurons
    Katharina Möller (Cologne, Germany)
    11:15-11:30 S12 Antibody – and osteoclast – dependent mechanisms of pain in rheumatoid arthritis
    Alexandra Jurczac (Stockholm, Sweden)
    11:30-12:30 L7 Unraveling the mysteries of complex persistent pain conditions
    Bill Maixner (Durham, NC, USA)
    13:00-15:00 Lunch break
    15:00-16:00 L8 The neural basis of phantom pains
    Tamar Makin (London, UK)
      Scholars’ oral presentations
    16:00-16:15 S13 Protein toxins of the Echis coloratus viper venom directly activate TRPV1
    Matan Geron (Jerusalem, Israel)
    16:15-16:30 S14 Intercostobrachial nerve resection in breast cancer surgery: patients with and without neuropathic pain 4 to 9 years after treatment
    Laura Mustonen (Helsinki, Finland)
    16:30-17:00 Coffee break
    17:00-17:15 S15 Intra-ganglionic delivery of Iba-1 siRNA is reducing the SNL-induced neuropathic pain
    Roxana-Olimpia Gheorghe (Bucharest, Romania)
    17:15-17:30 S16 Pain in osteoarthritis: role of cytokines, matrix metalloproteinases, and matrix metallo proteinase-generated biomarkers
    Maja Radojčić (Herlev, Denmark)
    17:30-18:30 L9 Diagnostic tests for assessing nociceptive pathways
    Andrea Truini (Rome, Italy)
    20:00-21:30 Dinner in the small Cloister
    21:30 W2 Organization of debate teams


  • Wednesday, 7 June

    9:00-10:00 L10 Trigeminal neuralgia: from pathophysiological mechanisms to clinical management
    Andrea Truini (Rome, Italy)
      Scholars’ oral presentations
    10:00-10:15 S17 Breaking dogmas. Paroxysmal pain is mediated by non-nociceptive large myelinated fibres. A neurophysiological study in normal humans
    Caterina Leone (Rome, Italy)
    10:15-10:30 S18 Motor map plasticity in chronic neuropathic facial pain and rTMS treatment effects
    Laura Lyydia Säisänen (Kuopio, Finland)
    10:30-11:00 Coffee break
    11:00-11:15 S19 Pain reduction by inducing sensory-motor adaptation: CRPS PRISMA trial
    Monika Halicka (Bath, UK)
    11:15-11:30 S20 Electrical stimulation of dorsal root ganglia (DRG) in animal models: a systematic review
    Ivana Vuka (Split, Croatia)
    11:30-12:30 L11 Assessing the pain code by intraneural recording in humans
    Jordi Serra (Barcelona, Spain)
    13:00-15:00 Lunch break
    15:00-16:00 L12 Translational pain research: targeting central sensitization in mice and humans
    Rob Gereau (St. Louis, MO, US)
      Scholars’ oral presentations
    16:00-16:15 S21 The nociceptin/orphaninFQ receptor system in a cancer-induced bone pain model
    Sonny Sliepen (Aachen, Germany)
    16:15-16:30 S22 Choice of rat strain and vendor, when performing pre-clinical pain-research - does it make a difference?
    Sara Hestehave (Copenhagen, Denmark)
    16:30-16:45 S23 Pharmacological targeting of spinal a2/a3 GABAARs reduces not only hyperalgesia but also the aversive component of on-going neuropathic pain
    Elena Neumann (Zurich, Switzerland)
    17:00-17:30 Coffee break
    17:30-18:30 L13 Role of melatonin on pain modulation
    Giancarlo Carli (Siena, Italy)
      W3 EPS2017 Neuropathic Pain Quiz!!
    Jordi Serra (Moderator)
    20:00-21:30 Dinner in the small Cloister
    21:30 Stargazing night... with the telescopes of the Astronomical Observatory of the University of Siena


  • Thursday, 8 June

    9:00-10:00 L14 Methodologies in clinical assessment of pain phenotypes: biopsychosocial factors
    Bill Maixner (Durham, NC, USA)
    10:00-10:30 W4 Duetto on pain-sensation and suffering
    Marshall Devor (Moderator)
    “If we could stop the pain, would the cognitive and psychosocial co-morbidities vanish?”
    Patrick Haggard and Bill Maixner
    10:30-11:00 Coffee break
    11:00-11:30 W4 Duetto on pain-sensation and suffering
    Marshall Devor (Moderator)
    “How can we tell if pain originates in the PNS or CNS?”
    Rob Gereau and Jordi Serra
    11:30-12:30 L15 An overview of psychological measurement theory for pain research
    Patrick Haggard (London, UK)
    13:00-15:00 Lunch break
      Afternoon and Evening: Excursion to Siena old town
    15:00-18:00 Guided tour to historical Siena, visit of the Cathedral and City Hall
    19:00-20:00 Aperitif in Piazza del Campo
    20:00-24:00 Free time for Scholars in Siena / Faculty Dinner
    (plan to return to the Certosa on your own)


  • Friday, 9 June

    9:00-10:00 L16 What can the thermal grill illusion tell us about pain perception?
    Patrick Haggard (London, UK)
      Scholars’ oral presentations
    10:00-10:15 S24 Novel first-in class selective melatonin MT2 receptor ligands alleviate neuropathic pain through modulation of brainstem descending antinociceptive pathways
    Luca Posa (Montreal, QC, Canada)
    10:15-10:30 S25 Measuring perceptual and neurometric sensitivity to experimental pain
    Stephanie Cook (London, UK)
    10:30-11:00 Coffee break
    11:00-11:15 S26 Investigating the first human loss-of-function mutation in TRPV1: the development of effective new therapy for inflammatory pain
    Tal Brandwine (Jerusalem, Israel)
    11:15-11:30 S27 The impact of trait mindfulness on sensory, cognitive and neurological aspects of pain
    Richard Harrison (Reading, UK)
    11:30-12:30 L17 Pain and consciousness
    Marshall Devor (Jerusalem, Israel)
    13:00-15:00 Lunch break
    15:00-16:00 L18 Hormonal modulation of pain
    Anna Maria Aloisi (Siena, Italy)
      Scholars’ oral presentations
    16:00-16:15 S28 Offset analgesia does not reflect temporal contrast enhancement
    Brianna Beck (London, UK)
    16:15-16:30 S29 Pharmacometric analysis as an approach for dose selection in pediatric populations with acute pain
    Anna Dari (Aachen, Germany)
    16:30-17:00 Coffee break
    17:00-17:15 S30 The role of candidate proteins in the production of slowly-adapting mechanically-activated currents and noxious mechanosensation
    Alice Fuller (London, UK)
    17:15-17:30 S31 Painful procedures during neonatal development: long-term consequences on spinal nociceptive anatomy and the opioid receptor OPRM1
    Nynke van den Hoogen (Bucharest, Romania)
    17:30-18:30 L19 Optogenetic tools for the study and treatment of pain
    Rob Gereau (St. Louis, MO, USA)
    20:00-21:30 Dinner in the small Cloister
    21:30 W6 Experiments in the pain laboratory – sensory dissociation during limb ischemia
    Jordi Serra (Barcelona, Spain)


  • Saturday, 10 June

    9:00-10:00 W7 Ethical considerations and limitations of pain research and treatment in humans and animals
    Manfred Zimmermann (Heidelberg, Germany)
    30 min presentation followed by a panel discussion of specific ethical issues, with Manfred Zimmerman, Jordi Serra, Marshall Devor and Faculty
    10:00-10:30 W8 Scholars’ controversial debates on the following topics
    Marshall Devor and Jordi Serra (Moderators)
    a) Resolved: “Intense focal pain is worse than diffuse widespread pain”
    10:30-11:00 Coffee break
    11:00-11:30 W8 Scholars’ controversial debates on the following topics
    Marshall Devor and Jordi Serra (Moderators)
    b) Resolved: “Transition to chronicity reflects failure of pain to resolve, not a change in the underlying biological process”
    11:30-12:00 W9 The relevance of IASP for pain researchers
    Lars Arendt-Nielsen (Aalborg, Denmark)
    12:00-12:30 W10 Evaluation of EPS 2017 by Scholars and Faculty, parting words
    - General discussion of the EPS experience and suggestions on how to modify/improve EPS in the future
    - Parting words from Anna Maria and Bill

    13:00-15:00 Lunch break
      Afternoon in Rapolano’s hot springs and aperitif
    20:00 Farewell dinner at the Certosa and... music